Recent Publications

Reviews

Thermos K. Somatostatin and Neuroprotection in Retina, in: Gravanis A./Mellon S (eds), Hormones in Neurodegeneration, Neuroprotection and Neurogenesis. Wiley-VCH, Weinheim. 2011. ISBN-10: 3-527-32627-8.

Vasilaki, A., Thermos, K. Somatostatin analogues as therapeutics in retinal disease. Pharmacology and Therapeutics 122:324-33, 2009.

Thermos, K. Novel signals mediating the function of somatostatin: the emerging role of NO/cGMP. Molecular and Cellular Endocrinology (invited review, Special Issue on Somatostatin and Cortistatin) 286: 49-57, 2008.

Thermos, K., Bagnoli, P., Epelbaum, J., Hoyer, D. The somatostatin sst1 receptor: An autoreceptor for somatostatin in brain and retina? Pharmacology and Therapeutics 110: 455-464, 2006

Thermos K. Functional mapping of somatostatin receptors in the retina: A review Vision Research 43: 1805-1815, 2003.

Retina Project

Kokona, D., Charalampopoulos, I., Pediaditakis, I., Gravanis, A., Thermos, K. The neurosteroid dehydroepiandrosterone (DHEA) protects the retina from AMPA-induced excitotoxicity: NGF TrkA receptor involvement. Neuropharmacology, 62:2106-17, 2012

Papadaki T, Tsilimbaris M, Pallikaris I, Thermos K. Somatostatin receptor activation (sst(1)-sst(5)) differentially influences human retinal pigment epithelium cell viability. Acta Ophthalmol 2010 Jul 13. [Epub ahead of print]

Kiagiadaki, F., Savvaki, M., Thermos, K. Activation of somatostatin receptor (sst5) protects the rat retina from AMPA-induced neurotoxicity. Neuropharmacology 58:297-303, 2010.

Kiagiadaki F. and Thermos, K. Somatostatin Receptor (sst2) agonists protect the retina from AMPA excitotoxicity: an in vivo study. Investigative Ophthalmology and Visual Science 49:380-389, 2008.

Mastrodimou, N., Kiagiadaki, F. and Thermos, K. The role of nitric oxide and cGMP in somatostatin’s protection of retinal ischemia. Investigative Ophthalmology and Visual Science 49:342-349, 2008.

Kiagiadaki, F., Koulakis, E., Thermos, K. Dopamine via D1 receptor activation and cGMP modulate somatostatin release in the rat retina. Experimental Eye Research 86:18-24, 2008.

Mastrodimou, N., Vasilaki, A., Papadioti, A., Low, M., Hoyer, D. and Thermos, K. Somatostatin receptors in wildtype and somatostatin deficient mice and their involvement in nitric oxide physiology. Neuropeptides 40:365-373, 2006.

Kouvidi, E., Daifoti, Z. and Thermos, K. Somatostatin receptors (sst1 and sst2) modulate dopamine release in the rat retina. Neuroscience Letters 391:82-86, 2006.

Mastrodimou, N., Kiagiadaki, F., Hodjarova, M., Karagiani, E and Thermos, K. Somatostatin modulates cGMP levels in the rat retina. Involvement of nitric oxide synthase. Regulatory Peptides 133: 41-46, 2006.

Mastrodimou, N., Lambrou, G., and Thermos, K. Effect of somatostatin, cortistatin and sst2 agonists on chemically induced ischemia in rat retina. Naunyn-Schmiedeberg’s Archives of Pharmacology 371: 44-53, 2005.

Vasilaki, A., Papadaki, T., Notas, G., Kolios, G., Mastrodimou, N., Hoyer, D, Tsilimbaris, M., Kouroumalis, E., Pallikaris, I. and Thermos, K. Somatostatin regulates nitric oxide production in human retinal pigment epithelium (RPE) cell cultures Investigative Ophthalmology & Visual Science 45:1499-506, 2004.

Brain Project

De Bundel D, Aourz N, Kiagiadaki F, Clinckers R, Hoyer D, Kastellakis A, Michotte Y, Thermos K, Smolders I. Hippocampal sst(1) receptors are autoreceptors and do not affect seizures in rats. Neuroreport 21:254-258, 2010

Pallis, E., Vasilaki A., Fehlmann, D., Kastellakis A., Hoyer, D., Spyraki, C. and Thermos, K. Acute and chronic administration of citalopram influences somatostatin levels and somatostatin receptor pharmacology in brain. Neuropsychopharmacology 34: 952-963, 2009.

Santis, S., Kastellakis, A., Kotzamani, D., Kokona, D., Pitarokoili,K. and Thermos, K. Somatostatin increases rat locomotor activity by activating sst2 and sst4 receptors in the striatum and via glutamatergic involvement. Naunyn-Schmiedeberg Archives of Pharmacology 379:181-189, 2009.

Marazioti, A., Spyraki, C., Thermos, K. GABA antagonists reverse the somatostatin dependent attenuation of rat locomotor activity. Neuropeptides 43:207-12, 2009.

Marazioti, A., Pitychoutis, P.M., Papadopoulou-Daifoti, Z., Spyraki, C., Thermos, K. Activation of somatostatin receptor in the globus pallidus increases rat locomotor activity and dopamine levels in the striatum. Psychopharmacology 201:413-422, 2008

Pallis, E., Spyraki, C., Thermos, K. Chronic antidepressant treatment modulates the release of somatostatin in the nucleus accumbens of the rat. Neuroscience Letters 395: 76-81, 2006.

Marazioti, A., Kastellakis, A., Antoniou, K., Papasava, D., Thermos, K. Somatostatin and analogs administered in the ventral pallidum decrease locomotor activity of rats. Psychopharmacology 181: 319-326, 2005.

Vasilaki, Α., Papasava, D., Hoyer, D., and Thermos, K. Somatostatin receptor (sst1) modulates the release of somatostatin in the nucleus accumbens. Neuropharmacology 47: 612-618, 2004.

Collaborative Projects on Somatostatin and Cancer Biology and Therapeutics

Notas, G., Kampa, M., Nifli, A.-P., Xidakis, K., Papasava, D., Thermos, K., Kouroumalis, E. And Castanas, E. The inhibitory effect of opioids on HepG2 cells is mediated via interaction with somatostatin receptors. European Journal of Pharmacology, 555: 1-7, 2007.

Xidakis, K., Notas, G., Mastrodimou, N., Kolios, G., Kouroumalis, E., Thermos, K.* RT-PCR and immunocytochemistry studies support the presence of somatostatin, cortistatin and somatostatin receptor subtypes in rat Kupffer cells. Regulatory Peptides 143: 76-82, 2007.

George Notas, George Kolios, Niki Mastrodimou, Marilena Kampa, Anna Vasilaki, Costas Xidakis, Elias Castanas, Kyriaki Thermos, Elias Kouroumalis Cortistatin production by HepG2 human hepatocellular carcinoma cell line and distribution of somatostatin receptors J. Hepatology 40:792-798, 2004.

Kouroumalis, E.A., Skordilis, P., Thermos, K., Vasilaki, A., Moschandrea, J. and Manousos, O.N. Treatment of hepatocellular carcinoma with octreotide: a randomized study. Gut 42: 442-447, 1998.

Hatzoglou, A., Ouafik, L’H., Bakogeorgiou, E., Thermos, K. and Castanas, E. Morphine cross-reacts with somatostatin receptors in the T47D human breast cancer cell line. Cancer Research 55: 5632-5636, 1995.